Indeed, ICAM-1-binding DBLβ domains occur in B- and C-type PfEMP1s that are associated with uncomplicated malaria as well as A-type PfEMP1s associated with severe disease, suggesting that ICAM-1 binding alone is not a driver of CM (Bengtsson et al., 2013, Howell et al., 2008, Janes et al., 2011). Here, ICAM1 is linked to malaria.