PPARA and dilated cardiomyopathy: In summary, the principal findings of this study are: 1) Iso exacerbates the cardiac phenotype in TazKD mice rapidly by inducing dilated cardiomyopathy and LV systolic dysfunction by 4.5 months of age, and 2) the pan-PPAR agonist BF effectively prevents development of LV dilation and LV systolic dysfunction in TazKD mice.