NOTCH1 and renal cell carcinoma: Therefore, we examined the expression of the 4 receptors and 5 ligands of notch pathway in RCC CSCs derived from ACHN and Caki-1 cells and found that Notch1, Notch2, Jagged1, Jagged2, DLL1 and DLL4 were significantly enhanced in RCC CSCs, suggesting that notch signaling pathways in RCC CSCs are aberrant activated.