It has been revealed that CD133, CD24, CD105, Snail, Nanog, Twist, OCT-3/4, CRT2, BCL-2,MDR1, KLF4 and so on are stemness markers in CSCs of renal cell carcinoma [13, 16] or other types of tumor [23, 24]. The gene discussed is KLF4; the disease is renal cell carcinoma.