NOTCH1 and renal cell carcinoma: Inhibition of notch1/2 by MRK-003 or Numb resulted in down-regulation of the stemness markers CTR2, BCL-2, OCT-4, KLF4 and MDR1 (Fig. 4e–h), reduced self-renewal (Fig. 4i and j), invasive and migration capability (Fig. 4k–n), enhanced sensitivity to cisplatin and sorafenib (Fig. 4o–r), and decreased tumorigenicity (Fig. 5a and Table 2) in RCC CSCs.