It was of interest to evaluate IMQ dermatitis in MOLF mice, since previous studies have identified MOLF genetic variants impacting Toll-like receptor (TLR) signaling, including alleles associated with Tlr5 [57], Irak1bp1 [56], Irak2 [70], Irak2c [71], and Cyld [72]. Here, CYLD is linked to dermatitis.