AKT1 and neoplasm: Given that mTOR signaling, which is aberrantly activated in lymphoma, plays a major role in tumor cell growth [146, 147]; Dong et al. demonstrated that HDAC inhibitors and mTOR inhibitors work synergistically to inhibit Burkitt B cell lymphomas showing constitutive activation of PI3K/Akt signaling and c-Myc overexpression [126].