ITCH and colorectal cancer: Cir-ITCH was shown to play an inhibitory role in the development and progression of colorectal cancer and esophageal squamous cell carcinoma and it may interact with the miRNAs (miR-7, miR-17, miR-214) thus increasing the level of ITCH, which works as inhibitor of Wnt /β-catenin signaling pathway, exerting an anti-neoplastic effect [75, 76].