The IL2RG subnetwork was associated with the increase of important pro-inflammatory molecules such as IL21 [93] but also with the decrease of molecules such as the inducible T cell costimulator ligand (ICOSLG), which is a pattern recognition element that may impact immune response [94], or the cytochrome P450 family member CYP2B6, which plays a role in mood disorders and depression [95]. This evidence concerns the gene IL21 and major depressive disorder.