A gene cluster centered on IL2RG was associated with several components of the Jak-Stat signaling pathway (p = 0.0002, Benjamini = 0.002), primary immunodeficiency (p = 0.008, Benjamini = 0.03), and cytokine-cytokine receptor interaction (p = 0.006, Benjamini = 0.06) pathways. Here, IL2RG is linked to inborn error of immunity.