Endotoxin-induced uveitis is a hyperacute form of anterior and intermediate uveitis that can be generated with systemic or intraocular injection of LPS, and has a significant infiltrate of CD45+, Ly6G+, Cd11b+ neutrophils at peak inflammation.12,19 This is a common model of uveitis that may be a good approximation of the mechanisms underlying HLA-B27–associated uveitis in humans.20 Endotoxin-induced uveitis was generated by intraocular injection of LPS and bioluminescence was determined at baseline before injection and 18 hours later (peak inflammation). Here, PTPRC is linked to uveitis.