When we investigated the interacting IBD susceptibility candidate genes for enriched GeneOntology terms, purine nucleotide biosynthetic processes were identified at rank 4 in HepG2 cells and at rank 13 in HEK293 cells, and were represented by the genes ADK, ADA, ADCY3, ADCY7 and GART. This evidence concerns the gene ADCY7 and inflammatory bowel disease.