The myeloid expansion observed here is consistent with reports of enhanced myelopoiesis in mice engineered to transgenically overexpress Tlr7 [45] and of monocytosis in aged male BXSB mice [46], a lupus model in which disease is driven by the yaa translocation that increases gene dosage of Tlr7 among others [47]. The gene discussed is TLR7; the disease is systemic lupus erythematosus.