To determine the effect of CpG1 and CpG2 methylation on GGH expression in leukemia cells and normal leukocytes, Real-time PCR was used to measure the abundance of GGH mRNA in leukemia cells and normal leukocytes (from peripheral blood when patients established complete remission (CR)) from 17 children with BNHD-ALL. This evidence concerns the gene GGH and acute lymphoblastic leukemia.