CCL2 and Other metabolic disease: Candidate factors linking visceral fat to LECT2 are adipokines, such as adiponectin, leptin, TNF-α, and MCP-1, which are derived from the visceral adipose tissue because these adipokines are mainly secreted from visceral adipose tissue rather than subcutaneous adipose tissue and were demonstrated to be key mediators linking visceral obesity to metabolic diseases [25].