INS and diabetes mellitus: In diabetes, amino acids and biogenic amines can point out the involvement of branched-chain amino acids in insulin resistance or the relationship of tryptophan and kynurenine with immune / inflammatory processes; acylcarnitines can help to assess mitochondrial function which affects inflammation and lipid accumulation in the liver; lipid metabolism may provide information on low grade inflammation, as lipids are considered as inflammatory mediators; the sum of hexoses can point out disturbed glucose homeostasis.