The median NLRs were 4.7 (range, 2.3–17.9) and 6.2 (2.0–48.8) (p = 0.001), DNI values were 0 (0–2.6) and 0.25 (0–4.7) (p = 0.006), and CRP levels were 3.3 (0.6–32.0) and 7.5 (0.6–65.2) (p = 0.008) in the PPROM with HCA group and PPROM without HCA group, respectively. The gene discussed is CRP; the disease is preterm premature rupture of the membranes.