Regardless of the type of inflammation-causing microorganisms in HCA, the proinflammatory cytokines that are secreted in the early stage of intrauterine inflammation, such as interleukin (IL)-6, IL-10, IL-1β, and tumor necrosis factor-α (TNF-α), flow into the bloodstream of pregnant women. This evidence concerns the gene IL10 and hepatocellular adenoma.