Sensitivity of tumor cells to TRAIL apoptosis may be restored by a number of substances and biological agents [61–66]: proteasome inhibitors, mainly, but not restricted to inhibition of NF-kB activation, AKT inhibition, mitogen-activated protein kinase (MAPK), protein kinase C (PKC) activation, reactive oxygen species, interferon, resveratrol, tunicamycin, histone deacetylase inhibitors, 2-methoxyestradiol, synthetic triterpenoids, peroxysome proliferators-activated receptor agonists, betulinic acid and telomerase-dependent virotherapy [61, 66]. This evidence concerns the gene AKT1 and neoplasm.