DUX4 and sarcoma: Moreover, our findings help explain the main pattern of oncogenic translocations resulting in CIC-DUX4 sarcomas (Fig 1B): it is not incidental that C1 is preserved in most CIC-DUX4 chimeras, since C1 should be required for effective CIC-DUX4 DNA binding and subsequent aberrant activation of ETV genes and other targets.