Bioinformatics analysis of the DNMT1 promoter showed that miR-377, with 7 bases predicted complementarily pairing with DNMT1 3′UTR, which has been shown to function as a tumor suppressor in various types of cancer cells, including clear cell renal cell carcinoma,35 malignant melanoma,36 hepatocellular carcinoma,25 osteosarcoma,26 glioblastoma,37 and prostate cancer cells,38 may regulate DNMT1. Here, DNMT1 is linked to Familial prostate cancer.