TP53 and skin aging: Knockdown of the Caenorhabditis elegans p53 gene (Cep-1) can increase lifespan.43 Furthermore, an epidemiological study showed that a mutation in the p53 protein (R72P) increases survival and contributes to aging.44 Recent data have suggested that p53 is an important inducer of organismal aging; for example, p53-mediated skin aging involves the loss of subdermal fat and declining sebaceous gland activity.45 In our study, we found that methylation of the p53 promoter was significantly altered after alterations in miR-377 expression in HSFs.