DNMT1 and gastric cancer: miR-377 has been reported to enhance fibronectin protein production,23 regulate angiogenesis,24 suppress cell proliferation,25, 26 predict clinical outcomes in patients with gastric cancer, induce tumorigenesis,27 and promote oxidative stress.28 Owing to the pleiotropic functions and DNMT1 targeting potential of miR-377, miR-377 may regulate human skin fibroblast (HSF) senescence by targeting DNMT1.