DNMT1 and osteosarcoma: Bioinformatics analysis of the DNMT1 promoter showed that miR-377, with 7 bases predicted complementarily pairing with DNMT1 3′UTR, which has been shown to function as a tumor suppressor in various types of cancer cells, including clear cell renal cell carcinoma,35 malignant melanoma,36 hepatocellular carcinoma,25 osteosarcoma,26 glioblastoma,37 and prostate cancer cells,38 may regulate DNMT1.