Twenty percent of all human lncRNAs have been shown to physically associate with Polycomb Repressive Complex 2 (PRC2 complex), suggesting that lncRNAs may have a universal role in recruiting polycomb-group proteins to their target genes.30 The previous research confirmed that BLACAT1(linc-UBC1) physically associates with PRC2 complex and regulates histone modification status of target genes in bladder cancer.22 Our results suggest that BLACAT1 serves as a member of PRC2-mediated epigenetic regulation and may participate in the occurrence and development of CRC. This evidence concerns the gene UBE2K and colorectal carcinoma.