For example, HOTAIR, functioning as an oncogene, that can be used to predict the prognosis in non-small cell lung cancer (NSCLC) patients and determine whether or not patient can benefit from chemotherapy.16, 17 GAS1 that downregulated in papillary thyroid cancer leaded to the activation of PI3K/Akt/Bad pathway and the promotion of proliferation.18 In colorectal cancer, MALAT1 and 91H can be used as predictive biomarker for poor prognosis,19, 20 UCA1 influences cell proliferation and apoptosis of colorectal cancer.21 This evidence concerns the gene AKT1 and colorectal cancer.