BLACAT1 (linc-UBC1) is one of the few well-known lincRNAs, with a length of 2616 bp and a functional role in recruiting and binding to polycomb repressive complex 2 (PRC2), first characterized in bladder cancers.22 Recent studies suggest BLACAT1 exhibited tumor pro-oncogenic activity in gastric cancer, and additionally may serve as an negative predictor for prognosis in GC patients.23 The biological roles of BLACAT1 in colorectal cancer have not been well understood, which prompted us to explore the functions of BLACAT1 in human colorectal cancer. This evidence concerns the gene UBE2K and colorectal cancer.