Along with others, we have shown that microRNA-27a (miR-27a), by targeting PPARγ, exacerbates renal tubulointerstitial fibrosis and mesangial cell injury in DN.20, 26 In this study, our aim was to explore whether miR-27a promotes podocyte injury through PPARγ-mediated β-catenin activation in DN. This evidence concerns the gene PPARG and liver dysplastic nodule.