BBC3 and neoplasm: Some studies have revealed that BCL2L1 and BCL2 have been shown to inhibit autophagy by binding to BECN1, an autophagy-inducing protein which contains a BH3 domain.45 According to present results, we speculate that BBC3, as a pro-apoptotic BH3-only protein, functions to induce autophagy through competitively disrupting the interaction between BECN1 and BCL2L1.17 A separate research46 shows that BBC3 is a substrate of chaperone-mediated autophagy (CMA) in human tumor cell lines, but inhibition of CMA results in stabilization of BBC3.