We showed that treatment with sorafenib and MEK inhibitors co-delivered by tumor-targeted NPs PEG-PLGA revealed more potent tumor growth inhibition effect when compared to the free-form drug cocktail without causing unwanted toxicity, indicating the CTCE-NP formulation could increase the therapeutic effects and therapeutic window of combined sorafenib and MEK inhibitors. This evidence concerns the gene MAP2K7 and neoplasm.