INS and diabetes mellitus: A systematic review on SGLT2i in addition to insulin therapy for management of DM indicated 34 individual case reports of DKA, 25 cases involved patients with a diagnosis of T2DM, and 13 cases of DKA were reported in SGLT2i in addition to insulin therapy, including 5 cases occurred in T2DM and 8 cases in T1DM36, However, No RCTs on T2DM received SGLT2i in combination with insulin reported DKA events37.