Several cases of DKA were reported with the use of SGLT-2 inhibitors for treatment of both T1DM and T2DM20, 21, 23, 24, 25, 28, 32, 33, 34, while different from typically DKA which is associated with marked hyperglycemia and resultant dehydration, majority of the cases were occurred with a mild hyperglycemia or normoglycemia, the latter one, known as euglycemic or normoglycemic DKA (a BG concentration of <200 mg/dL), that raising valid questions regarding their clinical use and safety. Here, SLC5A2 is linked to type 1 diabetes mellitus.