This unique mechanism of action and strong efficacy of SGLT-2 inhibitors in the treatment of T2DM suggested potential benefit for treatment of T1DM, and this theory has been explored and validated recently in several animal experiments and clinical studies17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28. Here, SLC5A2 is linked to type 2 diabetes mellitus.