Identification of Sphk1 as a key member of numerous pathways altered in hypertension, caused by chronic Ang II infusion, is important, as it is in line with the previous report by Wilson and colleagues who found Sphk1−/− mice to be protected against 2-weeks model of Ang II-induced hypertension26, which was not confirmed in the acute model of Ang II injection27. This evidence concerns the gene AGT and hypertensive disorder.