To determine whether MGCD0103 is also effective on spontaneously originated, intracranial SHH-MB, we injected Math1-Cre/Ptcfl/fl mice showing clinical signs of MB (i.e. ataxia, lack of coordination, reduced motility) with a bolus of MGCD0103 or vehicle for 6 hours. The gene discussed is ATOH1; the disease is cerebellar ataxia.