To our knowledge, it is unclear which factors can directly bind the region near rs619289, and no adjacent linkage disequilibrium variant could enable us to clarify how rs619289 might regulate MYBL2. Nonetheless, our present data and previous results conclusively show that individuals who carry the T allele of rs619289 have significantly greater MYBL2 expression and, consequently, elevated breast cancer risk and poorer outcome26. This evidence concerns the gene MYBL2 and breast carcinoma.