Comparative studies between WT and NV-deletion mutant IHNV or VHSV suggest that NV proteins may downregulate the induction of interferon (IFN) and interferon-stimulated genes (ISG) during in vitro infection of rainbow trout- or cyprinid-derived cell lines15, 23 and in vivo infection of olive flounder23. Here, STING1 is linked to infection.