In mLNs the frequencies and absolute numbers of CD103+ DCs are similarly reduced, both, under inflammatory conditions (Fig. 3c, upper panel) as well as in ABX-treated mice, which do not develop colitis (Fig. 3c, lower panel), suggesting that CD40-signalling induces robust DC-migration from LP to mLNs, but constitutive signalling in DC-LMP/CD40-mice would not lead to transient accumulation of DCs in mLN, as observed in acute treatment with anti-CD40 mAbs (Fig. 1b). This evidence concerns the gene CD40 and colitis.