Chareonsirisuthigul et al. 52 showed that the ADE infection pathway suppresses the innate anti-DENV mediator, the nitric oxide (NO) radical, by disrupting the transcription of the inducible nitric oxide synthase (iNOS) gene by TFIRF1, and blocking the activation of STAT1. Here, STAT1 is linked to acute disseminated encephalomyelitis.