Among the top ten hyper- and top ten hypo-methylated genes (Table 2), a subset (i.e., GABRB1, LC34A2, CLCN6, CLCA4, CYP3A43, CYP3A4, CYP2C9) has been related to epilepsy in epidemiological, pathophysiological or clinical context (to be discussed further). The gene discussed is CLCN6; the disease is epilepsy.