These gene signatures correlate, as expected, with the mRNA levels of their respective transcription factors (STAT1, Spearman's R=0.89; STAT3, Spearman's R=0.45) and with the phospho-protein levels (pY705-STAT3: Spearman's R=0.37; pY701-STAT1: data not available) in human breast tumours from the TCGA data set (Supplementary Fig. 11). This evidence concerns the gene STAT1 and breast neoplasm.