Although MT/Shc2F/2F breast cancer cells display reduced Y705-STAT3 phosphorylation in vitro (Fig. 3a), progressively growing MT/Shc2F/2F tumours (PD) that evolved in an immunocompetent background hyperactivated STAT3 compared with those that emerged in IFNγ−/− mice. The gene discussed is STAT3; the disease is breast carcinoma.