In two other studies, 5 μM of sodium arsenite (iAsIII) for 72 h in primary rat pancreatic β-cells reduced insulin mRNA expression [62] and 0.5 μM sodium arsenite in a rat insulinoma cell line suppressed Ca2+ influx, thereby inhibiting insulin vesicle packaging and impairing GSIS [63]. Here, INS is linked to pancreatic insulinoma.