Taken together, the suppression of the antitumor activity of CD8+ T cells in the ovarian cancer environment seems to be evoked by multiple mechanisms, which include (i) the inhibition of CD8+ T cell migration, (ii) the induction of inhibitory molecules on CD8+ T cells, and (iii) modulated CD8+ T cell activity by increased presence of Tregs. This evidence concerns the gene CD8A and ovarian cancer.