As a result, the ovarian cancer cells exert myosin-dependent mechanical forces on the mesothelial cell layer to promote the disruption of mesothelial intercellular junctions and retraction of mesothelial cells leading to gaps within the mesothelial cell layer that can be utilized by ovarian cancer cells to invade into the submesothelial matrix (184, 194). The gene discussed is MYH14; the disease is ovarian carcinoma.