Low-dose metronomic chemotherapy (MCT) described as the administration of chronic, equally spaced and, generally, low doses of chemotherapeutic drugs without extended rest periods, that allows chronic treatment with therapeutic efficacy and low toxicity, has been demonstrated to be effective in several types of tumours (breast, sarcoma, lung, prostate), the decrease in vascular endothelial growth factor being one of the demonstrated mechanisms of action [13–16], which results in an antiangiogenic effect. This evidence concerns the gene VEGFA and neoplasm.