PAMPs or DAMPS expressed on pathogens or tissue injury are recognized by a specialized pattern expressed on the host known as Pattern recognition receptors (PRR), including NOD-like receptors, TLR, trigger receptors on myeloid cells, inflammation-induced activation of innate immune cells and drive inflammation-induced cancer by production of cytokines mediated NF-kB activation [1–3]. This evidence concerns the gene NFKB1 and cancer.