TGFB1 and neoplasm: M2 polarisation induced by chronic inflammatory mediators IL-10,TGF-Beta, PGE2 and CSF-1, promotes tumour progression by releasing various mediators such as cytokines (IL-10,TGF-Beta, TNF-Alfa, IFN-Beta, PGE2,ROS), chemokines ( CCL18, CCL22, CCL17, CXCL8), growth factors (VEGF, PDGF, EGF, FGF, M-CSF) and proteinases (MMPs, Cathepsins) [15, 19, 22, 23, 25].