EGF and neoplasm: Induced by cytokines IL-4, IL-10, IL-13 down regulating IL-12 and MHC-Class 11 and release CCL17 ,CCL22 and CCL24 chemokines, which recruit Treg cells, basophils, eosinophils, B lymphocytes, bring about immunoregulation by suppressing Th1 response and poor antigen presentation, and also promote tumour progression by producing V EGF, IL-10 and TGF-Beta [3, 13, 26].