STAT3 and cancer: NF-KB activation in cancer cells by IL-1, TNF-Alfa proinflammatory cytokines, hypoxia, and ROI is expressed by leukocytes as well as the pathogen-associated molecular pattern (PAMP) and STAT-3 transcriptional factor, activated by IL-6 and EGF which in turn up-regulates HIF-1 responsible for cancer cell survival and tumour progression by cell proliferation, angiogenesis, genomic instability through anti-apoptotic activity, epithelial-mesenchymal transition, invasion, and metastasis [15, 20, 22, 29].