TNF and neoplasm: Tumour-associated neutrophils (N1 phenotype) exhibit antitumour activity in the early phase of the tumour through T cell responses by inhibiting TGF-Beta signalling,production of TNF-Alfa, NO, and H2O2 recruited to the tumour by chemokines such as (CXCL8, CXCL1, CXCL2, CXCL3, and CXCL5) and protumoural activity by TGF-Beta (N2phenotype) through the release of neutrophil elastase.