In mice bearing 4-nitroquinoline 1-oxide-induced lung hyperplasia, adenoma, and adenocarcinoma (182), fenofibrate downregulated the IGF axis by significantly reducing insulin and IGF-1 serum levels and the immunohistochemical expression of IGF-IR, pAkt, and pERK1/2, indicating a potential as chemoprevention agent. The gene discussed is IGF1; the disease is adenoma.