PPARG and breast cancer: For example, in breast cancer cells, PPAR-γ agonists induced autophagy through HIF-1α and BNIP3 upregulation (125), while in adrenocortical cancer cells, RGZ triggered autophagy by increasing the expression of AMPKα and beclin 1, through both PPAR-γ-dependent and PPAR-γ-independent mechanisms (126).