CASP3 and thyroid gland undifferentiated (anaplastic) carcinoma: For example, in lung cancer cells, TGZ reduces the antiapoptotic protein Bcl-2; in anaplastic thyroid cancer, RGZ-induced apoptosis is associated with decrease of B-cell lymphoma-extra large expression and caspase-3 and caspase-7 activation; in many hepatoma cell lines, RGZ induces apoptosis by promoting the expression of PTEN, caspase-3, and caspase-9 (95, 96).