Knowing that the mature forms of IL-1β and IL-18 are cleaved by MMP-9 (Schonbeck et al., 1998; Kawasaki et al., 2008) and/or nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3/caspase 1 (NLRP3/Casp-1) inflammasome complex (Franchi et al., 2009), we decided to examine the influence of CORM-2 on the activation of those factors in the neuropathic pain model. This evidence concerns the gene CASP1 and neuropathic pain.