A mixture of Curcuma longa and Boswellia serrata has been shown to be more efficient than a standard dose of celecoxib (a selective COX-2 inhibitor) in the treatment of osteoarthritis, improving both objectively and subjectively the condition of the patients, with no toxicity detectable by clinical examination and laboratory tests (hemogram, liver and renal function tests) [39]. This evidence concerns the gene PTGS2 and osteoarthritis.