In an animal arthritis model a preparation from CL lacking essential oil strongly suppressed joint inflammation and periarticular damage in correlation with decreased activation of NF-κB and of the ensuing cascade of events (involving mediators of inflammation and injury such as chemokines, cyclooxygenase 2, and receptor activator of nuclear factor kappa-B ligand (RANKL)) [49]. Here, TNFSF11 is linked to arthritic joint disease.