CLIC1 and acute pancreatitis: Since CLIC1 has been implicated in superoxide production by macrophages and microglia, and since superoxide is thought to play an important role in many models of acute tissue injury, we used our C1KO mice to look for a potential role for CLIC1 in two models of tissue injury in which superoxide production is thought to play a role, acute pancreatitis and acute toxic kidney injury.