Specifically, PPARG activation alongside WNT5A downregulation, seen during in vivo propagation, may represent a major determinant of AML pathogenesis, as these two factors are key regulators of MSC/pericyte fate decisions, and their unique expression status in AML could underlie the skewed MSC differentiation and consequently the cellular phenotypes characterizing AML. The gene discussed is WNT5A; the disease is acute myeloid leukemia.