HTT and Huntington disease: Moreover, we revealed that ER instability was enhanced in living neurons of two HD model mice (mutant Htt-Exon1-transgenic R6/2 mice [7] and mutant Htt-knock-in mice [17]) and showed that targeting the TEAD/YAP-mediated transcription or the Hippo pathway ameliorated the cell death and symptoms of HD model mice [8].