The level of anti-PD-1 is closely associated to malar rash (OR = 15.773; 95% CI 3.065–81.186), arthritis (OR = 22.937; 95% CI 4.619–113.9), serositis (OR = 16.008; 95% CI 2.119–120.967), hematological (OR = 35.187; 95% CI 6.459–191.679), renal (OR = 8.306; 95% CI 1.323–52.132), and neurological involvement (OR = 37.282; 95% CI 1.497–928.697). This evidence concerns the gene PDCD1 and Arthritis.