FOXO3 and breast cancer: 2012), antiproliferative effect in breast cancer MCF-7 cells (Cunha et al. 2012), an effect recently reported to be associated with oxidative stress, necrosis, and apoptosis induced by AMP-activated protein-kinase (AMPK) and the Forkhead transcription factor, FOXO3a (Queiroz et al. 2015).