FUS and amyotrophic lateral sclerosis: Specifically, we examined post-mortem CNS tissues derived from ALS individuals harboring different FUS mutations (Supplemental Table S2), including R521G, H517Q, a splice site mutation (ex14del) that causes skipping of exon14, P525L and a base pair deletion (bp1408del) (A1-A5, respectively, in Fig. 5).