Several examples have demonstrated this influence in vivo: CCR2 knock-out (KO) and CCR5 KO mice were protected from dextran-sulfate sodium (DSS)-induced intestinal adhesions, mucosal ulcerations, and colonic inflammation as a consequence of the IL-10 increase and the IFN-γ decrease; CCL2/MCP-1 KO mice have a markedly reduced severity of colitis and reduced mortality rate13. The gene discussed is CCR5; the disease is colitis.