Among 22 SNPs, five SNPs (CSK rs1378942, CSK-MIR4513 rs3784789, uncharacterized LOC101929750 (LOC101929750) rs7554672, muskelin 1 (MKLN1) rs1643270, teneurin transmembrane protein 4 (TENM4) rs10466739) showed significant interactions between 24 h estimated urinary factors and the risk of hypertension. The gene discussed is MKLN1; the disease is Hypertension.