The strongest protective effects of variants of CSK rs1378942 (p-interaction = 0.013; OR = 0.08; 95% CIs = 0.01–0.67) and CSK-MIR4513 rs3784789 (p-interaction = 0.027; OR = 0.08; 95% CIs = 0.01–0.72) on the risk of hypertension was found in the second tertile for the 24HUNa-K ratio. This evidence concerns the gene CSK and Hypertension.