PRKN and Parkinson disease: Mutations in the FBX07 (F-box protein 7) gene, encoding an adaptor protein in Skp–Cullin–F-box (SCF) SCF(FBXO7) ubiquitin E3 ligase complex, to recognize substrates and mediate substrate ubiquitination by SCF(FBXO7) E3 ligase, are also associated with PD.