The study conducted by Shen and colleagues recognized the effect of up-regulated miR-29a-3p in exacerbating doxorubicin-resistance in breast cancer cell lines, through its regulatory function on PTEN and GSK3β, that are two major components of the PTEN/AKT/GSK3β signalling pathway providing feedback to TP53 [55]. Here, PTEN is linked to breast carcinoma.