IGF1R and lung adenocarcinoma: This particular study recognised the effect of GAS5 in enhancing apoptosis due to gefitinib activity within innate EGFR tyrosine-kinase inhibitor (TKI) resistant lung adenocarcinomas (A549 cell line), through the gene regulating role of GAS5 on insulin-like growth factor 1 receptor (IGF-1R) [240].