Li et al. reported that QQ-reagent (a protein transduction reagent)-modified cardiac transcription factors, such as mouse Gata4 (GATA binding protein 4), Hand2 (heart- and neural crest derivatives-expressed protein 2), Mef2c (myocyte-specific enhancer factor 2C), and Tbx5 (T-box transcription factor 5) (mGHMT), were sufficient to reprogram HDFs into cardiac progenitor cells (CPCs), which could improve cardiac function after myocardial infarction [48]. This evidence concerns the gene TBX5 and myocardial infarction.