NOS2 and synucleinopathy: For example, miR-155 knockout mice showed reduced microgliosis and neuroprotection despite α-Syn overexpression.82 miR-155 was also observed to be essential for α-Syn-induced major histocompatibility complex class II (MHCII) and inducible nitric oxide synthase (iNOS) expression in microglia.82 Although further studies are needed, these findings not only provide mechanisms by which α-Syn levels are regulated in disease brains but also raise the possibility that miRNA based therapy is feasible for α-Synucleinopathies.