Particularly, hyperphosphorylation of Tau promotes neuronal degeneration, and the fibrillar deposits of highly phosphorylated Tau is a defining marker of neurodegeneration including.203 Studies in PD and AD models showed co-localization of α-Syn with phospho-GSK-3β and phospho-Tau, and indicated that α-Syn may act as a scaffolding molecule that is necessary for the activation of GSK-3β and the subsequent Tau hyperphosphorylation.204,205 Taken together, these studies indicate that LRRK2 may be critically involved in the Tau pathology in PD. This evidence concerns the gene GSK3B and Alzheimer disease.