SNCA and Alzheimer disease: Ishimaru et al.84 and Polymeropoulos et al.85showed that a brief global ischemia in gerbils resulted in increased α-Syn (aka precursor protein of non-Aβ component of AD amyloid; NACP) immunoreactivity in the hippocampus where neurons died and proposed that NACP may be related to several neurodegenerative conditions.