MAPT and Parkinson disease: In addition, polymorphism within the LRRK2 gene is also correlated with sporadic PD risk.192,193 Many studies further showed that LRRK2 variants that include A419V, R1628P, and G2385R mutations increase risk for sporadic PD in Asians.194, –196 Interestingly, there might be an association between LRRK2 and other PD genes; and many PD patients with LRRK2 mutations exhibit α-Syn-positive Lewy bodies and tau-related pathology.197,198