Moreover, treatment of two different cancer cell lines, MCF7 (breast) and SK-HEP-1 (liver) (Bollard et al., 2016), with a CDK4/6 inhibitor (Palbociclib or Palbo), mimicking TIS, also triggered endogenous upregulation of β3 (Figures 4C, S3C, and S3D). This evidence concerns the gene CDK4 and cancer.